Xu, Lin , Zhao, Zhong , Meyer, Denise , Shen, Wen-Hui .
Histone methylation in flowering time regulation.
Flowering represents a crucial transition from a vegetative to a reproductive phase of the plant life cycle. The MADS-box transcription factor, FLOWERING LOCUS C (FLC), plays a key role in flowering time regulation in Arabidopsis. While methylations at histone H3K9 and H3K27 repress FLC expression, methylations at H3K4 and H3K36 activate FLC expression. We showed that loss-of-function mutations in SET DOMAIN GROUP8 (SDG8), a gene encoding the yeast SET2 histone methyltransferase homolog, results in reduced dimethylation of H3K36, particularly in chromatin associated with the FLC promoter and first intron, regions that contain essential cis-elements for transcription (Zhao et al., 2005, Nature Cell Biology 7:1256-1260). Our more recent work expended the role of SDG8 in histone methylation at FLC and other genes, establishing SDG8 as a histone methyltransferase critical in Arabidopsis growth and development.
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1 - IBMP-CNRS, Cell Biology, 12 rue du General Zimmer, Strasbourg, 67084, France
Presentation Type: Plant Biology Abstract
Location: Exhibit Hall (Northeast, Southwest & Southeast)/Hilton
Date: Sunday, July 8th, 2007
Time: 8:00 AM