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Abstract Detail

Protein Targeting and Vesicular Trafficking

Kuppu, Sundaram [1], Venkataramani, Sujatha [2], Zhang, Hong [3].

The role of AKR2 in the biogenesis of some membrane proteins.

Protein-protein interaction plays an important role in controlling protein stability, protein targeting, and signal transduction. Stabilizing and targeting of membrane-bound proteins to their destinations are vital for plant growth and development. Therefore, understanding the mechanism of stabilization and targeting of these membrane-bound proteins is very important. Earlier research in our laboratory had shown that ankyrin repeat-containing protein 2 (AKR2) interacts with the peroxisomal membrane-bound ascorbate peroxidase 3 (APX3). AKR2 also interacts with other membrane-bound proteins such as cytochrome b5 (CB5), cytochrome b5 reducates (CB5R) and the chloroplast outer envelop proteins OEP7. The AKR2-interaction sites in these membrane proteins are their transmembrane domains. Consequently, we hypothesized that AKR2 might regulate the biogenesis of these membrane proteins. To test our hypothesis we are [1] studying the role of AKR2 in plant growth and development by analyzing AKR2 down-expression lines (via RNA interference) and [2] analyzing the localization and behavior of GFP-APX3 fusion proteins in AKR2 down-expression lines (including RNA interference lines, AKR2 tilling mutants, and AKR2 antisense lines). This research will lead to a better understanding of the role that AKR2 plays in the biogenesis of a group of membrane-bound proteins and elucidating a mechanism about the roles that AKR2 plays in plant growth and development, disease resistance, and antioxidation metabolism at molecular level. Most recent data on the characterization of AKR2 down-expression lines will be presented at the meeting.

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1 - Texas Tech University, Biological Sciences, pobox 43131, Lubbock, Texas, 79409, United States of America
2 - The University of Chicago, Molecular Genetics & Cell Biology
3 - Texas Tech University, Biological Sciences

protein targeting.

Presentation Type: Plant Biology Abstract
Session: P
Location: Exhibit Hall (Northeast, Southwest & Southeast)/Hilton
Date: Sunday, July 8th, 2007
Time: 8:00 AM
Number: P22015
Abstract ID:502

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