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Abstract Detail


Metabolism

Babka, Heather L [1], Fatland-Bloom, Beth L [2], Choi, Suh-Yeon [1], Nikolau, Basil J [2], Wurtele, Eve [3].

Transcriptomic and Metabolomic Analysis of Antisense ATP-Citrate Lyase Arabidopsis thaliana Supplemented with Malonic Acid.

ATP-citrate lyase (ACL) catalyzes the production of acetyl-CoA in the cytosol of Arabidopsis thaliana. The cytosolic pool of acetyl-CoA is required for the production of the stress-related phytochemicals, stilbenoids and flavonoids, and for elongation of fatty acids. In addition, cytosolic acetyl-CoA is essential for the synthesis of membrane sterols. Antisense ACL plants have reduced ACL activity, and a very distinct phenotype including miniature organs, smaller cells, reduced cuticular wax, and an increased accumulation of starch. This phenotype is reversed by exogenous malonic acid, which feeds into the carboxylation pathway of acetyl-CoA metabolism (Fatland et al., 2004). Antisense ACL and wildtype plants with and without treatment with malonic acid were analyzed by transcriptomics and metabolomics. These analyses are providing clues as to the mechanisms that Arabidopsis employs to cope with a decreased level of ACL activity in planta.


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1 - Iowa State University, Interdepartmental Genetics Program, Department of Genetics, Development, and Cell Biology
2 - Iowa State University, Department of Biochemistry and Biophysics
3 - Iowa State University, Department of Genetics, Development, and Cell Biology

Keywords:
Acetyl-CoA
ATP-Citrate Lyase
malonic acid
ACL.

Presentation Type: Plant Biology Abstract
Session: P
Location: Exhibit Hall (Northeast, Southwest & Southeast)/Hilton
Date: Sunday, July 8th, 2007
Time: 8:00 AM
Number: P19020
Abstract ID:483


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