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Abstract Detail

Growth and Vegetative Development

Chen, Hao [1], Xiong, Liming [2].

Myo-inositol-1-phosphate Synthase is Required for PIN2 Cycling and Organ Development.

The phytohormone auxin plays many pivotal roles in plant growth and development. Auxin functions are largely dependent on its asymmetric distribution within tissues and organs. This auxin gradient is dynamically maintained by the polarized localization of a network of auxin efflux and influx carriers. These membrane proteins undergo continuous vesicle-dependent cycling between the plasma membrane and the intracellular compartments. Phosphatidylinositides are known to be essential for multiple steps of vesicle trafficking in eukaryotic cells. Inositol is a precursor of these phospholipids, yet the role of de novo inositol biosynthesis in regulating phosphatidylinositols and vesicle trafficking is unclear in higher eukaryotes. Here we report that Arabidopsis mutants defective in myo-inositol-1-phosphate synthase 1 (MIPS1) have reduced levels of phosphatidylinositols and display various patterning defects in embryogenesis, vascular development, and root cap organization. The mutant roots are also agravitropic and have greatly reduced basipetal auxin transport. We found that mips1 mutants are defective in endocytosis and are impaired in the cycling of the auxin efflux carrier PIN2. Our study indicates that de novo inositol biosynthesis controls phosphatidylinositols levels and provides strong evidence that phospholipids regulate the trafficking of auxin efflux carriers, thus controlling polar auxin transport and pattern formation in plants.

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Related Links:

1 - Donald Danforth Plant Science Center, 975 N Warson Rd., St Louis, MO, 63132, USA
2 - Donald Danforth Plant Science Center

Auxin transport
pattern formation
PIN2 cycling.

Presentation Type: Plant Biology Abstract
Session: P
Location: Exhibit Hall (Northeast, Southwest & Southeast)/Hilton
Date: Sunday, July 8th, 2007
Time: 8:00 AM
Number: P26068
Abstract ID:2451

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