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Abstract Detail


Education & Outreach

Mobach, Janina [1], Bestman, Hank D. [2].

Using dynamic modelling to illustrate the link between labelled carbon distribution and flux rates in a metabolic network.

As part of our research investigating the rate of carbon metabolism through the central carbon metabolic network in unicellular organisms, a MatLab-based computer program was developed (modeled after Wittmann and Heinzle, 1999, Biotechnol. Bioeng. 62:739-750). This program models how changing metabolic flux rates affect the isotopomer distribution ratios of metabolic intermediates and their derived amino acids. It can be used as a teaching tool to demonstrate this relationship. The same model can be used in a research setting to verify the flux rates calculated by such metabolic flux analysis programs as FiatFlux (Zamboni, Fischer and Sauer, 2005, BMC Bioinformatics) and 13C-Flux (Wiechert, 2001, Metabolic Engineering, 3:195-206). In our laboratory we have used this model to verify results reported in the literature and those obtained from our experiments investigating the central carbon metabolic pathway in the photosynthetic unicellular freshwater alga Chlamydomonas reinhardtii.


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1 - The King's University College, Biology, 9125 50 Street, Edmonton, AB, T6B 2H3, Canada
2 - The King's University College, Biology and Center for Molecular Structure

Keywords:
modelling
isotopomer
metabolic flux.

Presentation Type: Plant Biology Abstract
Session: P
Location: Exhibit Hall (Northeast, Southwest & Southeast)/Hilton
Date: Sunday, July 8th, 2007
Time: 8:00 AM
Number: P46020
Abstract ID:1993


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