Holland, Jennifer J. , Celaya, R. Brandon , Barr, Jason , Liscum, Mannie , Alexander, Stephen .
Elucidating a role for sphingolipids in plant development.
Sphingolipid metabolism is a conserved process across taxa and specific metabolites play integral roles in regulating numerous cellular processes, such as cell proliferation, cell signaling, differentiation, stress responses, and providing structural support to the plasma membrane and tonoplast. The importance of sphingolipids in basic cellular processes has been elucidated in a number of fungal and animal systems, including Saccharomyces cerevisiae, Dictyostelium discoideum, Caenorhabditis elegans, Drosophila melangaster, mouse, and human. Disrupting sphingolipid metabolism in any of these organisms results in profound effects on membrane composition, cell to cell signaling, cell proliferation/death, and development. Research in Arabidopsis thaliana has underscored that particular sphingolipids are important for membrane integrity, stress responses, pathogenesis, control of cell proliferation and death and signaling in plants, like other organisms. In addition to these potential roles for sphingolipid metabolites in plants, recent findings from studies performed in our laboratories suggest that these compounds also play a role in the regulation of plant development, specifically in fertilization. We have found that specific mutations affecting sphingolipid metabolism result in a male-derived disruption of fertilization that appears to result from a failure of male and female gametophyte communication. Results on recent genetic and cell biology studies to examine these events in detail will be described.
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1 - University of Missouri-Columbia, Division of Biolgical Sciences, 302 Christopher S. Bond Life Sciences Center, Columbia, MO, 65203, US
2 - University of Missouri-Columbia, Division of Biological Sciences
Presentation Type: Plant Biology Abstract
Location: Exhibit Hall (Northeast, Southwest & Southeast)/Hilton
Date: Sunday, July 8th, 2007
Time: 8:00 AM