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Abstract Detail

Evolutionary Developmental Biology (Evo-Devo)

Correa, Raul [1], Baum, David A. [2].

Evolutionary Transgenomics: A New Screen to Identify Genes that Explain Species Differences.

An evolutionary transgenomic screen entails the introduction of genomic inserts from a donor species into a recipient species followed by phenotypic screening of the transgenic lines. Phenotypic effects caused by trangenes can theoretically be due to either gene dosage or evolutionary divergence of the donor and recipient species, all of which are of potential developmental and/or evolutionary interest. Dosage effects can be identified by seeing if the homologous region of the recipient speciesí genome can cause the same effect when introduced as a supernumerary copy. Evolutionary divergence can be imperfectly divided into two main kinds: phenotypic divergence and developmental system drift. Phenotypic divergence refers to cases in which a major gene has contributed to the phenotypic divergence of the donor and recipient species, in which case an insert containing this gene could convert the recipient species to resemble the donor species for this phenotype. In cases where the transformants manifest a phenotype seen in neither species, developmental system drift is implied: divergence in genetic interactions such that genes from one species behave as gain-of-function mutant alleles in the other genetic background. We will present one such case that illustrates the potential of transgenomics to discover formerly cryptic developmental roles for even well-characterized genes. Among the many interesting phenotypes that can be discovered by such an approach, cases of dominant sterility or lethality have important implications for our understanding of the evolution of reproductive isolation in allopatry. We present results from a proof-of-concept transgenomic screen of Leavenworthia alabamica in an Arabidopsis thaliana background.

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1 - University of Wisconsin, Botany and Genetics, 430 Lincoln Drive, Madison, WI, 53706, USA
2 - University of Wisconsin Madison, Department of Botany, Birge Hall, 430 Lincoln Drive, Madison, Wisconsin, 53706-1381, USA

genetic screen
Genetic basis of species diifferences
Evolutionary Developmental Genetics.

Presentation Type: Oral Paper:Papers for Topics
Session: CP46
Location: Astoria Room/Hilton
Date: Wednesday, July 11th, 2007
Time: 9:00 AM
Number: CP46003
Abstract ID:1888

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