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Abstract Detail


Intracellular Signaling

Taylor, Ann [1], Pedley, Kerry [2], Martin, Gregory [3].

Involvement of a Dual Specificity Protein Phosphatase In Plant Defense Responses.

Plants protect themselves from pathogens with a variety of responses, including the production of oxidants, synthesis of antimicrobial proteins, and localized cell death referred to as the hypersensitive response. One common feature of these responses is changes in the phosphorylation state of the plant cell. While the kinases in these processes have been well-characterized, the phosphatases have not been studied as extensively. Ten candidate phosphatases were silenced using virus-induced gene silencing and surveyed for the impact on cell death. One phosphatase that was identified in this screen and as an interactor with a known MAP kinase in a yeast two hybrid screen was further characterized. Over-expression of this dual specificity phosphatase inhibited cell death initiated by MAPKKKα. Point mutations in the conserved phosphatase active site were made, but the mutated phosphatases were still able to inhibit the kinase induced cell death.


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1 - Wabash College, Chemistry, 301 W Wabash Avenue, Crawfordsville, IN, 47933, USA
2 - USDA Agricultural Research Service, Foreign Disease-Weed Science Research Unit
3 - Cornell University, Boyce Thompson Institute

Keywords:
phosphatase
MAP kinase.

Presentation Type: Plant Biology Abstract
Session: P
Location: Exhibit Hall (Northeast, Southwest & Southeast)/Hilton
Date: Sunday, July 8th, 2007
Time: 8:00 AM
Number: P33017
Abstract ID:1081


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